Literature summary for 6.1.1.1 extracted from

Greenberg, Y.; King, M.; Kiosses, W.B.; Ewalt, K.; Yang, X.; Schimmel, P.; Reader, J.S.; Tzima, E.
The novel fragment of tyrosyl tRNA synthetase, mini-TyrRS, is secreted to induce an angiogenic response in endothelial cells (2008), FASEB J., 22, 1597-1605.

Search for more literature for 6.1.1.1

Application

Application	Comment	Organism
medicine	it is shown that mini-TyrRS is exported from endothelial cells when they are treated with tumor necrosis factor-alpha. Mini-TyrRS binds to vascular endothelial cells and activates an array of angiogenic signal transduction pathways. Mini-TyrRS-induces angiogenesis requires the activation of VEGF receptor-2. Mini-TyrRS stimulates VEGFR2 phosphorylation in a VEGF-independent manner, suggesting VEGFR2 transactivation	Bos taurus

Protein Variants

Protein Variants	Comment	Organism
E91N	mutation of the ELR motif: mutant protein does not induce phosphorylation of VEGFR2, suggesting that the ELR motif in mini-TyrRS has an important role in transactivation of VEGFR2	Bos taurus
L92Y	mutation of the ELR motif: mutant protein does not induce phosphorylation of VEGFR2, suggesting that the ELR motif in mini-TyrRS has an important role in transactivation of VEGFR2	Bos taurus
R93Q	mutation of the ELR motif: mutant protein does not induce phosphorylation of VEGFR2, suggesting that the ELR motif in mini-TyrRS has an important role in transactivation of VEGFR2	Bos taurus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
43000	-	Western blot	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell line	bovine aortic endothelial cells	Bos taurus	-

Synonyms

Synonyms	Comment	Organism
Tyrosyl-tRNA synthetase	-	Bos taurus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)