Literature summary for 6.1.1.1 extracted from

Bonnefond, L.; Fender, A.; Rudinger-Thirion, J.; Giege, R.; Florentz, C.; Sissler, M.
Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS (2005), Biochemistry, 44, 4805-4816.

Search for more literature for 6.1.1.1

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression in Escherichia coli	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00052	-	tRNATyr	pH 7.6, 37°C, native Escherichia coli tRNATyr	Homo sapiens
0.0048	-	tRNATyr	pH 7.6, 37°C, human mitochondrial tRNATyr	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	human mitochondrial and cytosolic enzymes are encoded by two different sets of genes	Homo sapiens	5739	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
51302	-	2 * 51302, calculation from amino acid sequence	Homo sapiens
130000	-	gel filtration	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y2Z4	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-tyrosine + tRNATyr	the enzyme aminoacylates Escherichia coli tRNA as well as in vitro transcribed human mitochondrial tRNAs	Homo sapiens	AMP + L-Tyr-tRNATyr + diphosphate	-	?

Subunits

Subunits	Comment	Organism
dimer	2 * 51302, calculation from amino acid sequence	Homo sapiens

Synonyms

Synonyms	Comment	Organism
TyrRS	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
additional information	-	additional information	-	Homo sapiens

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Release 2023.1 (January 2023)