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Literature summary for 5.6.2.4 extracted from
- Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs (2013), Nat. Commun., 4, 2338 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293T and HeLa S3 cells | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 124000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3`-5` DNA helicase | - |
Homo sapiens |
| HELQ | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens |  |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | genetic disruption of the enzyme human cells enhances cellular sensitivity and chromosome radial formation by the interstrand crosslink-inducing agent mitomycin C | Homo sapiens |
| physiological function | the enzyme operates in DNA repair and cell cycle checkpoint signalling in response to interstrand crosslinks. The enzyme participates in a pathway of resistance to DNA interstrand crosslinks and is associated with the RAD51 paralogs RAD51B/C/D and XRCC2, and with the DNA damage-responsive kinase ATR which suggests the enzyme as a candidate ovarian cancer gene | Homo sapiens |
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