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Literature summary for 5.6.2.4 extracted from

  • Monroe, D.S. Jr.; Leitzel, A.K.; Klein, H.L.; Matson, S.W.
    Biochemical and genetic characterization of Hmi1p, a yeast DNA helicase involved in the maintenance of mitochondrial DNA (2005), Yeast, 22, 1269-1286.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.15
-
ATP pH 7.5, 30°C Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion mitochondrial localization of Hmi1p is essential for its role in mtDNA metabolism Saccharomyces cerevisiae 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ ATP hydrolysis in the presence of MgCl2 is 2fold higher than in the presence of either MnCl2 or CaCl2 Saccharomyces cerevisiae
Mg2+ ATP hydrolysis in the presence of MgCl2 is 2fold higher than in the presence of either MnCl2 or CaCl2 Saccharomyces cerevisiae
Mn2+ ATP hydrolysis in the presence of MgCl2 is 2fold higher than in the presence of either MnCl2 or CaCl2 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Saccharomyces cerevisiae DNA helicase Hmi1p is involved in the maintenance of mitochondrial DNA ADP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q12039
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
Saccharomyces cerevisiae ADP + phosphate
-
?
ATP + H2O DNA helicase Hmi1p is involved in the maintenance of mitochondrial DNA Saccharomyces cerevisiae ADP + phosphate
-
?

Synonyms

Synonyms Comment Organism
Hmi1p
-
Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.2
-
ATP pH 7.5, 30°C Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Saccharomyces cerevisiae