Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ssDNA | stimulates ATPase activity | Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | Streptococcus pneumoniae | PcrA is a chromosomally encoded DNA helicase of gram-positive bacteria involved in replication of rolling circle replicating plasmids | ADP + phosphate | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | Q8DPU8 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | PcrA is a chromosomally encoded DNA helicase of gram-positive bacteria involved in replication of rolling circle replicating plasmids | Streptococcus pneumoniae | ADP + phosphate | - |
? | |
ATP + H2O | hydrolyzes both ATP and dATP at similar levels. The enzyme shows 5' to 3' and 3' to 5' DNA helicase activities and binds efficiently to partially duplex DNA containing a hairpin structure adjacent to a 6-nucleotide 5' or 3' single-stranded tail and one unpaired (flap) nucleotide in the complementary strand | Streptococcus pneumoniae | ADP + phosphate | - |
? | |
dATP + H2O | hydrolyzes both ATP and dATP at similar levels. The enzyme shows 5' to 3' and 3' to 5' helicase activities and binds efficiently to partially duplex DNA containing a hairpin structure adjacent to a 6-nucleotide 5' or 3' single-stranded tail and one unpaired (flap) nucleotide in the complementary strand | Streptococcus pneumoniae | dADP + phosphate | - |
? | |
additional information | the enzyme is inefficient in in vitro replication of pT181, and perhaps as a consequence, this plasmid can not be established in Streptococcus pneumoniae | Streptococcus pneumoniae | ? | - |
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Synonyms | Comment | Organism |
---|---|---|
PcrA helicase | - |
Streptococcus pneumoniae |
PcrASpn | - |
Streptococcus pneumoniae |