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Literature summary for 5.6.2.4 extracted from

  • Shankar, J.; Tuteja, R.
    UvrD helicase of Plasmodium falciparum (2007), Gene, 410, 223-233.
    View publication on PubMed
Search for more literature for 5.6.2.4

Application

Application Comment Organism
medicine UvrD helicase is a potential drug targets for chemotherapy of malaria. As Plasmodium falciparum contains only one homologue of UvrD helicase and human lacks this helicase, detailed studies including cloning and characterization of UvrD helicase of malaria parasite may be helpful in identifying a compound that has no effect on the cellular machinery of the host and consequently could be used as the potential drug for the treatment of malaria Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
170000
-
 calculated from sequence Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Plasmodium falciparum helicases play an essential role in nearly all the nucleic acid metabolic processes, catalyzing the transient opening of the duplex nucleic acids in an ATP-dependent manner ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q8I3W6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Plasmodium falciparum ADP + phosphate
-
 ?
ATP + H2O helicases play an essential role in nearly all the nucleic acid metabolic processes, catalyzing the transient opening of the duplex nucleic acids in an ATP-dependent manner Plasmodium falciparum ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
UvrD helicase
-
 Plasmodium falciparum

pI Value

Organism Comment pI Value Maximum pI Value
Plasmodium falciparum calculated from sequence
-
 8