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Literature summary for 5.6.2.4 extracted from
- Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans (2008), Biochemistry, 47, 7583-7593.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| replication protein A | from Caenorhabditis elegans, stimulates helicase activity | Caenorhabditis elegans |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Caenorhabditis elegans |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | little or no unwinding is observed when Mg2+ was replaced with Zn2+ | Caenorhabditis elegans |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | Caenorhabditis elegans | the ability of CeWRN-1 to unwind DNA structures may improve the access for DNA repair and replication proteins that are important for preventing the accumulation of abnormal structures, contributing to genomic stability | ADP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | Q19546 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Caenorhabditis elegans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | the ability of CeWRN-1 to unwind DNA structures may improve the access for DNA repair and replication proteins that are important for preventing the accumulation of abnormal structures, contributing to genomic stability | Caenorhabditis elegans | ADP + phosphate | - |
? | |
| ATP + H2O | ATP-dependent 3' to 5' helicase capable of unwinding a variety of DNA structures such as forked duplexes, Holliday junctions, bubble substrates, D-loops, and flap duplexes, and 3'-tailed duplex substrates | Caenorhabditis elegans | ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CeWRN-1 | - |
Caenorhabditis elegans |
| WRN-1 RecQ helicase | - |
Caenorhabditis elegans |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Caenorhabditis elegans |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | 37 | similar active at 20°C, 30°C and 37°C | Caenorhabditis elegans |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Caenorhabditis elegans |
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