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Literature summary for 5.6.2.2 extracted from

  • Manohar, M.; Choi, H.W.; Manosalva, P.; Austin, C.A.; Peters, J.E.; Klessig, D.F.
    Plant and human MORC proteins have DNA-modifying activities similar to type II topoisomerases, but require one or more additional factors for full activity (2017), Mol. Plant Microbe Interact., 30, 87-100 .
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
etoposide the ATPase inhibitor does not affect the DNA relaxation and catenation activities of the enzyme Homo sapiens
etoposide the ATPase inhibitor does not affect the DNA relaxation and catenation activities of the enzyme Solanum lycopersicum
geldanamycin geldanamycin suppresses the ATPase activity of the enzyme Homo sapiens
geldanamycin geldanamycin suppresses the ATPase activity of the enzyme Solanum lycopersicum
radicicol radicicol suppresses the ATPase activity of the enzyme Homo sapiens
radicicol radicicol suppresses the ATPase activity of the enzyme Solanum lycopersicum
razoxane the ATPase inhibitor does not affect the DNA relaxation and catenation activities of the enzyme Homo sapiens
razoxane the ATPase inhibitor does not affect the DNA relaxation and catenation activities of the enzyme Solanum lycopersicum
salicylic acid salicylic acid suppresses the ATPase and decatenation but not relaxation activity of the enzyme Homo sapiens
salicylic acid salicylic acid suppresses the ATPase and decatenation but not relaxation activity of the enzyme Solanum lycopersicum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for ATPase activity Homo sapiens
Mg2+ required for ATPase activity Solanum lycopersicum
Mn2+ required for ATPase activity Homo sapiens
Mn2+ required for ATPase activity Solanum lycopersicum
additional information not influenced by K+, Na+, or Ni2+ Homo sapiens
additional information not influenced by K+, Na+, or Ni2+ Solanum lycopersicum

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Solanum lycopersicum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + catenated kinetoplast DNA
-
 Homo sapiens ADP + phosphate + decatenated kinetoplast DNA
-
 ?
ATP + catenated kinetoplast DNA
-
 Solanum lycopersicum ADP + phosphate + decatenated kinetoplast DNA
-
 ?
ATP + decatenated DNA
-
 Homo sapiens ADP + phosphate + catenated DNA
-
 ?
ATP + decatenated DNA
-
 Solanum lycopersicum ADP + phosphate + catenated DNA
-
 ?
ATP + negatively supercoiled pER8:hemagglutinin plasmid DNA
-
 Homo sapiens ADP + phosphate + relaxed pER8:hemagglutinin plasmid DNA
-
 ?
ATP + negatively supercoiled pER8:hemagglutinin plasmid DNA
-
 Solanum lycopersicum ADP + phosphate + relaxed pER8:hemagglutinin plasmid DNA
-
 ?
ATP + supercoiled pUC19 DNA
-
 Homo sapiens ADP + phosphate + nicked pUC19 DNA
-
 ?
ATP + supercoiled pUC19 DNA
-
 Solanum lycopersicum ADP + phosphate + nicked pUC19 DNA
-
 ?
ATP + supercoiled pUC19 DNA
-
 Homo sapiens ADP + phosphate + relaxed pUC19 DNA
-
 ?
ATP + supercoiled pUC19 DNA
-
 Solanum lycopersicum ADP + phosphate + relaxed pUC19 DNA
-
 ?

Synonyms

Synonyms Comment Organism
DNA topoisomerase II
-
 Homo sapiens
DNA topoisomerase II
-
 Solanum lycopersicum
microrchidia protein
-
 Homo sapiens
microrchidia protein
-
 Solanum lycopersicum
MORC1
-
 Homo sapiens
MORC1
-
 Solanum lycopersicum
topo II
-
 Homo sapiens
topo II
-
 Solanum lycopersicum