Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-Naphthoquinone | - |
Homo sapiens | |
10-chloro-7-(3-(dimethylamino)propyl)-3-methoxybenzo[a]phenazin-5(7H)- one | - |
Homo sapiens | |
10-chloro-7-(3-(dimethylamino)propyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
3-[(10-methoxybenzo[a]phenazin-5-yl)oxy]-N,N-dimethylpropan-1-amine | - |
Homo sapiens | |
7-(2-(4-methylpiperazin-1-yl)ethyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(2-(diethylamino)ethyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(2-(dimethylamino)ethyl)-3-methoxybenzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(2-(dimethylamino)ethyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(2-(piperidin-1-yl)ethyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(2-morpholinoethyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(3-(4-methylpiperazin-1-yl)propyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(3-(diethylamino)propyl)-3-methoxybenzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(3-(diethylamino)propyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(3-(dimethylamino)propyl)-10-methoxybenzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(3-(dimethylamino)propyl)-2-methoxybenzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(3-(dimethylamino)propyl)-3,10-dimethoxybenzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(3-(dimethylamino)propyl)-3,9-dimethoxybenzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(3-(dimethylamino)propyl)-3-methoxybenzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(3-(dimethylamino)propyl)-9-methoxybenzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(3-(dimethylamino)propyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(3-(dimethylamino)propyl)benzo[f]pyrido[2,3-b]quinoxalin-5(7H)-one | - |
Homo sapiens | |
7-(3-(piperidin-1-yl)propyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(3-(piperidin-1-yl)propyl)benzo[f]pyrido[2,3-b]quinoxalin-5(7H)-one | - |
Homo sapiens | |
7-(3-(pyrrolidin-1-yl)propyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(3-morpholinopropyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(4-(diethylamino)butyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-(4-(dimethylamino)butyl)benzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
7-propylbenzo[a]phenazin-5(7H)-one | - |
Homo sapiens | |
benzo[a]phenazine | - |
Homo sapiens | |
camptothecin | - |
Homo sapiens | |
NC-190 | - |
Homo sapiens | |
VP-16 | - |
Homo sapiens | |
XR 11576 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P11388 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
HL-60 cell | - |
Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + supercoiled pBR322 plasmid DNA | - |
Homo sapiens | ADP + phosphate + relaxed pBR322 plasmid DNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
topo II | - |
Homo sapiens |
Topoisomerase II | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00006 | - |
enzyme from HL-60 cell, at pH 8.0 and 37°C | Homo sapiens | VP-16 | |
0.00007 | - |
enzyme from HL-60 cell, at pH 8.0 and 37°C | Homo sapiens | camptothecin | |
0.00054 | - |
enzyme from HeLa cell, at pH 8.0 and 37°C | Homo sapiens | VP-16 | |
0.00164 | - |
enzyme from K-562 cell, at pH 8.0 and 37°C | Homo sapiens | VP-16 | |
0.00537 | - |
enzyme from K-562 cell, at pH 8.0 and 37°C | Homo sapiens | camptothecin | |
0.00891 | - |
enzyme from A-549 cell, at pH 8.0 and 37°C | Homo sapiens | VP-16 | |
0.01162 | - |
enzyme from HeLa cell, at pH 8.0 and 37°C | Homo sapiens | camptothecin | |
0.02645 | - |
enzyme from A-549 cell, at pH 8.0 and 37°C | Homo sapiens | camptothecin |