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Literature summary for 5.6.2.2 extracted from
- Topoisomerase IIbeta and its role in different biological contexts (2017), Arch. Biochem. Biophys., 633, 78-84 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme creates ATP-dependent transient double strand breaks in a segment of DNA, passage of un-broken segment of DNA though these transient breaks followed by re-ligation of broken-ends | Homo sapiens | ? | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DNA topoisomerase IIbeta | - |
Homo sapiens |
| Top2b | - |
Homo sapiens |
| type II DNA topoisomerase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays a role in different types of DNA repair pathways and is associated with neuronal development, HIV-infection, cancer, and the processes of aging | Homo sapiens |
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