Any feedback?
Literature summary for 5.6.2.2 extracted from
- Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol (2005), Nucleic Acids Res., 33, 2310-2317.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | geldanamycin does not inhibit the decatenation and relaxation activities | Saccharolobus shibatae | |
| radicicol | inhibits the decatenation and relaxation activities | Saccharolobus shibatae |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharolobus shibatae | O05207 and O05208 | O05207: subunit B, O05208: subunit A | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| catenated DNA + ATP + H2O | decatenation | Saccharolobus shibatae | minicircular DNA + ADP + phosphate | - |
? | |
| relaxed pBR322 plasmid + ATP + H2O | supercoiling | Saccharolobus shibatae | supercoiled pBR322 plasmid + ADP + phosphate | - |
? | |
| supercoiled pBR322 plasmid + ATP + H2O | relaxation | Saccharolobus shibatae | relaxed pBR322 plasmid + ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DNA topoisomerase VI | - |
Saccharolobus shibatae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 74 | - |
assay at | Saccharolobus shibatae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Saccharolobus shibatae |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
