Literature summary for 5.6.2.2 extracted from

Zhao, W.; Chen, L.; Li, H.M.; Wang, D.J.; Li, D.S.; Chen, T.; Yuan, Z.P.; Tang, Y.J.
A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation (2014), Bioorg. Med. Chem., 22, 2998-3007.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-N-(2-pyrazinecarboxylic) amino-4'-demethylepipodophyllotoxin	-	Homo sapiens
4-N-(3,4,5-trihydroxybenzoic) amino-4'-demethylepipodophyllotoxin	-	Homo sapiens
4-N-(5-methylpyrazine-2-carboxylic)amino-4'-demethylepipodophyllotoxin	-	Homo sapiens
4-N-(theophylline-7-acetic) amino-4'-demethylepipodophyllotoxin	-	Homo sapiens
4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin	-	Homo sapiens
4-O-(2-quinoline carboxylic)-4'-demethylepipodophyllotoxin	-	Homo sapiens
4-O-(5-methylpyrazine-2-carboxylic)-4'-demethylepipodophyllotoxin	-	Homo sapiens
4-O-(fluoroquinolonic)-4'-demethylepipodophyllotoxin	-	Homo sapiens
4-O-(theophylline-7-acetic)-4'-demethylepipodophyllotoxin	-	Homo sapiens
additional information	rational design strategy of podophyllum topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation, overview. The compounds exhibit promising in vitro antitumor activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
HeLa cell	-	Homo sapiens	-
Hep-G2 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
topo II	-	Homo sapiens
Topoisomerase II	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8.3	-	assay at	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
additional information	-	cytotoxic activity of inhibitory compounds, docking study, overview	Homo sapiens	additional information

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Release 2023.1 (January 2023)