Literature summary for 5.6.2.2 extracted from

Hajbi, Y.; Neagoie, C.; Biannic, B.; Chilloux, A.; Vedrenne, E.; Baldeyrou, B.; Bailly, C.; Merour, J.Y.; Rosca, S.; Routier, S.; Lansiaux, A.
Synthesis and biological activities of new furo[3,4-b]carbazoles: potential topoisomerase II inhibitors (2010), Eur. J. Med. Chem., 45, 5428-5437.

Inhibitors

Inhibitors	Comment	Organism
(3,5-dimethoxybenzene)-propynoic acid	-	Homo sapiens
(3,5-dimethoxybenzene)-propynoic acid methyl ester	-	Homo sapiens
1,3-benzodioxole-5-carbaldehyde	-	Homo sapiens
1-(2,2-dibromoethenyl)-3,5-dimethoxybenzene	-	Homo sapiens
1-(2,2-dibromoethenyl)-4-methoxybenzene	-	Homo sapiens
1-benzenesulfonyl-3-chloropropenyl-1H-indole	-	Homo sapiens
1-benzenesulfonyl-5-benzyloxy-3-chloropropenyl-1H-indole	-	Homo sapiens
3,4,5-trimethoxybenzaldehyde	-	Homo sapiens
3,4,5-trimethoxyphenylpropynoic-3-(1-benzenesulfonyl-1H-indol-3-yl)-allyl ester	-	Homo sapiens
3,4-dimethoxybenzaldehyde	-	Homo sapiens
3,4-dimethoxyphenylpropynoic-3-(1-benzenesulfonyl-1Hindol-3-yl)-allyl ester	-	Homo sapiens
3,4-methylenedioxyphenylpropynoic-3-(1-benzenesulfonyl-1H-indol-3-yl)-allyl ester	-	Homo sapiens
3,5-dimethoxybenzaldehyde	-	Homo sapiens
3,5-dimethoxyphenylpropynoic-3-(1-benzenesulfonyl-1H-indol-3-yl)-allyl ester	-	Homo sapiens
3-(1,3-benzodioxol-5-yl)prop-2-ynoic acid	-	Homo sapiens
3-(3,4,5-trimethoxyphenyl)prop-2-ynoic acid	-	Homo sapiens
3-(3,4-dimethoxyphenyl)prop-2-ynoic acid	-	Homo sapiens
3-(4-methoxyphenyl)prop-2-ynoic acid	-	Homo sapiens
3-[(1E)-3-chloroprop-1-en-1-yl]-1-(phenylsulfonyl)-1H-indole	-	Homo sapiens
4-(2,2-dibromoethenyl)-1,2-dimethoxybenzene	-	Homo sapiens
4-(3,4,5-trimethoxyphenyl)-1,5-dihydro-3H-furo[3,4-b]carbazol-3-one	-	Homo sapiens
4-methoxybenzaldehyde	-	Homo sapiens
4-methoxyphenylpropynoic-3-(1-benzenesulfonyl-1Hindol-3-yl)-allyl ester	-	Homo sapiens
5-(2,2-dibromoethenyl)-1,2,3-trimethoxybenzene	-	Homo sapiens
5-(2,2-dibromoethenyl)-1,3-benzodioxole	-	Homo sapiens
9-benzenesulfonyl-4-(3,4,5-trimethoxyphenyl)-1,5-dihydro-H-furo[3,4-b]carbazol-3-one	-	Homo sapiens
9-benzenesulfonyl-4-(3,4-dimethoxyphenyl)-1,5-dihydro-3H-furo[3,4-b]carbazol-3-one	-	Homo sapiens
9-benzenesulfonyl-4-(3,4-methylenedioxyphenyl)-1,5-dihydro-3H-furo[3,4-b]carbazol-3-one	-	Homo sapiens
9-benzenesulfonyl-4-(3,5-dimethoxyphenyl)-1,5-dihydro-3H-furo[3,4-b]carbazol-3-one	-	Homo sapiens
9-benzenesulfonyl-4-(4-methoxyphenyl)-1,5-dihydro-3Hfuro[3,4-b]carbazol-3-one	-	Homo sapiens
etoposide	-	Homo sapiens
methyl 3-(1,3-benzodioxol-5-yl)prop-2-ynoate	-	Homo sapiens
methyl 3-(3,4,5-trimethoxyphenyl)prop-2-ynoate	-	Homo sapiens
methyl 3-(3,4-dimethoxyphenyl)prop-2-ynoate	-	Homo sapiens
methyl 3-(4-methoxyphenyl)prop-2-ynoate	-	Homo sapiens
additional information	DNA binding, topoisomerase inhibition and cytotoxic properties of 1,5-dihydro-4-(substituted phenyl)-3H-furo[3,4-b]carbazol-3-ones, synthesised via a key step Diels-Alder reaction under microwave irradiation, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	substrate is supercoiled plasmid DNA	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
Topoisomerase II	-	Homo sapiens