Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | transport of the T-segment through the transiently cleaved G-DNA segment and the opened C-gate is via a free diffusion mechanism, opening and closing dynamics of the C-gate, two-gate model for chemomechanical coupling of topoisomerase II, detailed overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
DNA topoisomerase II | - |
Homo sapiens |
topo II | - |
Homo sapiens |
Topoisomerase II | - |
Homo sapiens |
type II DNA topoisomerase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | dynamics of ATP-dependent T-transport | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | DNA topoisomerase II is a homodimeric molecular machine that uses ATP hydrolysis to untangle DNA by passing one double-stranded DNA duplex, T-segment, through another double-stranded duplex, G-segment. Dynamics of ATP-dependent T-transport, overview | Homo sapiens |