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Literature summary for 5.6.2.2 extracted from

  • Xie, P.
    Dynamics of strand passage catalyzed by topoisomerase II (2010), Eur. Biophys. J., 39, 1251-1259.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information transport of the T-segment through the transiently cleaved G-DNA segment and the opened C-gate is via a free diffusion mechanism, opening and closing dynamics of the C-gate, two-gate model for chemomechanical coupling of topoisomerase II, detailed overview Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
homodimer
-
Homo sapiens

Synonyms

Synonyms Comment Organism
DNA topoisomerase II
-
Homo sapiens
topo II
-
Homo sapiens
Topoisomerase II
-
Homo sapiens
type II DNA topoisomerase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP dynamics of ATP-dependent T-transport Homo sapiens

General Information

General Information Comment Organism
physiological function DNA topoisomerase II is a homodimeric molecular machine that uses ATP hydrolysis to untangle DNA by passing one double-stranded DNA duplex, T-segment, through another double-stranded duplex, G-segment. Dynamics of ATP-dependent T-transport, overview Homo sapiens