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Literature summary for 5.6.2.2 extracted from
- Control of the flow properties of DNA by topoisomerase II and its targeting inhibitor (2010), Biophys. J., 99, 1906-1915.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenylyl-imidodiphosphate | i.e. AMP-PNP. In mixtures of AMP-PNP and ATP, the double-strand passage reaction of the enzyme gets blocked and progressively fewer entanglements are relaxed. A total replacement of ATP by AMP-PNP results in a temporal increase in elasticity at higher frequencies, but no transition to an elastic gel with fixed cross-links | Homo sapiens |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| topoisomerase IIalpha | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.9 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | double-strand passage facilitated by topoisomerase II controls DNA rheology, effect of topoisomerase II on the viscoelasticity, mechanism analysis using a system with bacteriophage lambda-DNA, the entanglements can be relaxed by topoisomerase II in conjunction with the consumption of ATP, overview | Homo sapiens |
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Release 2023.1 (January 2023)
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