Crystallization (Comment) | Organism |
---|---|
crystal structure analysis, overview | Homo sapiens |
crystal structure analysis, overview | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens | |
Mg2+ | required | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | P06786 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | DNA cleavage, aperture, closure and religation are critical steps in the topo II reaction cycle, topo II DNA gate dynamics, single-molecule FRET experiments, role of T-segment in gate opening, overview | Homo sapiens | ? | - |
? | |
additional information | DNA cleavage, aperture, closure and religation are critical steps in the topo II reaction cycle, topo II DNA gate dynamics, single-molecule FRET experiments, role of T-segment in gate opening, overview | Saccharomyces cerevisiae | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | determination and analysis of N- nad C-terminal fragments, comparison to the enzyme from Saccharomyces cerevisiae, overview. The N-terminal region bears the characteristic GHKL ATP-binding fold, while the C-terminal region comprises the transducer domain | Homo sapiens |
dimer | determination and analysis of N- nad C-terminal fragments, comparison to the human enzyme, overview. The N-terminal region bears the characteristic GHKL ATP-binding fold, while the C-terminal region comprises the transducer domain | Saccharomyces cerevisiae |
dimer | determination and analysis of N- and C-terminal fragments, comparison to the enzyme from Saccharomyces cerevisiae, overview. The N-terminal region bears the characteristic GHKL ATP-binding fold, while the C-terminal region comprises the transducer domain | Homo sapiens |
dimer | determination and analysis of N- and C-terminal fragments, comparison to the human enzyme, overview. The N-terminal region bears the characteristic GHKL ATP-binding fold, while the C-terminal region comprises the transducer domain | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
topo II | - |
Homo sapiens |
topo II | - |
Saccharomyces cerevisiae |
Topoisomerase II | - |
Homo sapiens |
Topoisomerase II | - |
Saccharomyces cerevisiae |
type II DNA topoisomerase | - |
Homo sapiens |
type II DNA topoisomerase | - |
Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | required | Homo sapiens | |
ATP | required | Saccharomyces cerevisiae |