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Literature summary for 5.6.2.2 extracted from

  • Collins, T.R.; Hammes, G.G.; Hsieh, T.S.
    Analysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspective (2009), Nucleic Acids Res., 37, 712-720.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure analysis, overview Homo sapiens
crystal structure analysis, overview Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-
nucleus
-
Saccharomyces cerevisiae 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens
Mg2+ required Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae P06786
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information DNA cleavage, aperture, closure and religation are critical steps in the topo II reaction cycle, topo II DNA gate dynamics, single-molecule FRET experiments, role of T-segment in gate opening, overview Homo sapiens ?
-
?
additional information DNA cleavage, aperture, closure and religation are critical steps in the topo II reaction cycle, topo II DNA gate dynamics, single-molecule FRET experiments, role of T-segment in gate opening, overview Saccharomyces cerevisiae ?
-
?

Subunits

Subunits Comment Organism
dimer determination and analysis of N- nad C-terminal fragments, comparison to the enzyme from Saccharomyces cerevisiae, overview. The N-terminal region bears the characteristic GHKL ATP-binding fold, while the C-terminal region comprises the transducer domain Homo sapiens
dimer determination and analysis of N- nad C-terminal fragments, comparison to the human enzyme, overview. The N-terminal region bears the characteristic GHKL ATP-binding fold, while the C-terminal region comprises the transducer domain Saccharomyces cerevisiae
dimer determination and analysis of N- and C-terminal fragments, comparison to the enzyme from Saccharomyces cerevisiae, overview. The N-terminal region bears the characteristic GHKL ATP-binding fold, while the C-terminal region comprises the transducer domain Homo sapiens
dimer determination and analysis of N- and C-terminal fragments, comparison to the human enzyme, overview. The N-terminal region bears the characteristic GHKL ATP-binding fold, while the C-terminal region comprises the transducer domain Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
topo II
-
Homo sapiens
topo II
-
Saccharomyces cerevisiae
Topoisomerase II
-
Homo sapiens
Topoisomerase II
-
Saccharomyces cerevisiae
type II DNA topoisomerase
-
Homo sapiens
type II DNA topoisomerase
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP required Homo sapiens
ATP required Saccharomyces cerevisiae