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Literature summary for 5.6.2.2 extracted from

  • Hu, C.; Xu, D.; Du, W.; Qian, S.; Wang, L.; Lou, J.; He, Q.; Yang, B.; Hu, Y.
    Novel 4 beta-anilino-podophyllotoxin derivatives: design synthesis and biological evaluation as potent DNA-topoisomerase II poisons and anti-MDR agents (2010), Mol. Biosyst., 6, 410-420.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
(5R,5aR,8aS,9S)-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-(1H-pyrrolo[2,3-b]pyridin-6-ylamino)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
-
 Homo sapiens
(5R,5aR,8aS,9S)-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-(4H-1,2,4-triazol-3-ylamino)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
-
 Homo sapiens
(5R,5aR,8aS,9S)-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-(9H-purin-6-ylamino)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
-
 Homo sapiens
(5R,5aR,8aS,9S)-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-(imidazo[1,2-a]pyridin-8-ylamino)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
-
 Homo sapiens
(5R,5aR,8aS,9S)-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-{[3-(methylamino)pyridin-2-yl]amino}-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
-
 Homo sapiens
(5R,5aR,8aS,9S)-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-{[3-(piperidin-1-ylmethyl)phenyl]amino}-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one molecular docking to MDR protein Homo sapiens
(5R,5aR,8aS,9S)-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-{[3-(pyrrolidin-1-ylmethyl)phenyl]amino}-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
-
 Homo sapiens
(5R,5aR,8aS,9S)-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-{[4-(piperidin-1-ylmethyl)phenyl]amino}-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
-
 Homo sapiens
(5R,5aR,8aS,9S)-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-{[4-(pyrrolidin-1-ylmethyl)phenyl]amino}-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
-
 Homo sapiens
(5R,5aR,8aS,9S)-9-({3-[(diethylamino)methyl]phenyl}amino)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
-
 Homo sapiens
(5R,5aR,8aS,9S)-9-({4-[(diethylamino)methyl]phenyl}amino)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
-
 Homo sapiens
(5R,5aR,8aS,9S)-9-[(5,6-diphenyl-1,2,4-triazin-3-yl)amino]-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
-
 Homo sapiens
(5R,5aR,8aS,9S)-9-[(6-aminopyridin-2-yl)amino]-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
-
 Homo sapiens
etoposide
-
 Homo sapiens
additional information design, synthesis, and inhibitory potencies of 4beta-anilino-podophyllotoxin analogues, derived from etoposide, overview. The compounds stabilize the covalent TopoII-DNA cleavage complex by inhibiting the TopoII-mediated religation reaction, in vitro antiproliferation activities against three drug-resistance tumor cell lines Homo sapiens
podophyllotoxin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
U-251 cell
-
 Homo sapiens
-
U-251 MG cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
DNA-topoisomerase II
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 in vitro antiproliferation activities against three drug-resistance tumor cell lines of 4beta-anilino-podophyllotoxin analogues, IC50 values Homo sapiens additional information