Literature summary for 5.6.2.2 extracted from

Chen, Z.; Liang, X.; Zhang, H.; Xie, H.; Liu, J.; Xu, Y.; Zhu, W.; Wang, Y.; Wang, X.; Tan, S.; Kuang, D.; Qian, X.
A new class of naphthalimide-based antitumor agents that inhibit topoisomerase II and induce lysosomal membrane permeabilization and apoptosis (2010), J. Med. Chem., 53, 2589-2600.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-(3-(2-(dimethylamino)ethylamino)propyl)-6-(dodecylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione	-	Homo sapiens
2-(3-(2-(dimethylamino)ethylamino)propyl)-6-(octylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione	-	Homo sapiens
2-(3-(4-methylpiperazin-1-yl)propyl)-6-(octylamino)-1H-benzo-[de]isoquinoline-1,3(2H)-dione	-	Homo sapiens
2-(3-(dimethylamino)propyl)-6-(methylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione	-	Homo sapiens
2-(3-(dimethylamino)propyl)-6-(octylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione	-	Homo sapiens
2-dodecyl-6-(2-(4-methylpiperazin-1-yl)ethylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione	-	Homo sapiens
2-dodecyl-6-(octylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione	-	Homo sapiens
6-(2-(2-(dimethylamino)ethylamino)ethylamino)-2-dodecyl-1H-benzo[de]isoquinoline-1,3(2H)-dione	-	Homo sapiens
6-(2-(2-(dimethylamino)ethylamino)ethylamino)-2-octyl-1H-benzo[de]isoquinoline-1,3(2H)-dione	-	Homo sapiens
6-(2-(4-methylpiperazin-1-yl)ethylamino)-2-octyl-1H-benzo[de]isoquinoline-1,3(2H)-dione	-	Homo sapiens
6-(2-(dimethylamino)ethylamino)-2-dodecyl-1H-benzo[de]isoquinoline-1,3(2H)-dione	-	Homo sapiens
6-(dodecylamino)-2-(3-(4-methylpiperazin-1-yl)propyl)-1H-benzo-[de]isoquinoline-1,3(2H)-dione	-	Homo sapiens
amonafide	-	Homo sapiens
doxorubicin	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
carcinoma cell	-	Homo sapiens	-
HeLa cell	a cervical carcinoma cell line	Homo sapiens	-
HL-60 cell	a promyelocytic leukemia cell line	Homo sapiens	-
LS-174T cell	a colon adenocarcinoma cell line	Homo sapiens	-
MCF-7 cell	a caucasian breast adenocarcinoma cell line	Homo sapiens	-
MKN-45 cell	a gastric cancer cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	DNA intercalating, relaxation, and decantenation of supercoiled pBR322 DNA	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
TOPOII	-	Homo sapiens
Topoisomerase II	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	8	assay at, dependent on reaction step	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
additional information	-	in vivo IC50 values of inhibitors in different cancer cell lines in a cytotoxicity assay, overview	Homo sapiens	additional information

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Release 2023.1 (January 2023)