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Literature summary for 5.6.2.2 extracted from

  • Pham, M.H.; Kondapalli, N.; Reckord, C.L.; Foglesong, P.D.
    Interleukin-2 induces the activities of DNA topoisomerase I and DNA topoisomerase II in HuT 78 cells (2009), Biochem. Biophys. Res. Commun., 390, 577-580.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus soluble Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens human cells can rapidly activate and deactivate DNA topoisomerase II in response to a signal molecule, the activity of DNA topoisomerase I is highly regulated in HuT 78 cells upon treatment with interleukin-2, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially from Hut 78 cells by nuclear extract preparation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HUT-78 cell a human cutaneous T cell lymphoma cell line Homo sapiens
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T-cell
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Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
quantitative detection of enzyme activity in Hut-78 cells over several hours after transient induction by interleukin-2, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information human cells can rapidly activate and deactivate DNA topoisomerase II in response to a signal molecule, the activity of DNA topoisomerase I is highly regulated in HuT 78 cells upon treatment with interleukin-2, overview Homo sapiens ?
-
?
additional information substrate is pBR322 supercoiled DNA Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
DNA topoisomerase II
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme expression is transiently induced up to 11fold by interleukin-2 at 1000 U/ml after 10 h up