Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | soluble | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | human cells can rapidly activate and deactivate DNA topoisomerase II in response to a signal molecule, the activity of DNA topoisomerase I is highly regulated in HuT 78 cells upon treatment with interleukin-2, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme partially from Hut 78 cells by nuclear extract preparation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HUT-78 cell | a human cutaneous T cell lymphoma cell line | Homo sapiens | - |
T-cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
quantitative detection of enzyme activity in Hut-78 cells over several hours after transient induction by interleukin-2, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | human cells can rapidly activate and deactivate DNA topoisomerase II in response to a signal molecule, the activity of DNA topoisomerase I is highly regulated in HuT 78 cells upon treatment with interleukin-2, overview | Homo sapiens | ? | - |
? | |
additional information | substrate is pBR322 supercoiled DNA | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA topoisomerase II | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme expression is transiently induced up to 11fold by interleukin-2 at 1000 U/ml after 10 h | up |