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Literature summary for 5.6.2.2 extracted from

  • Park, S.W.; Parrott, A.M.; Fritz, D.T.; Park, Y.; Mathews, M.B.; Lee, C.G.
    Regulation of the catalytic function of topoisomerase II alpha through association with RNA (2008), Nucleic Acids Res., 36, 6080-6090.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.2

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
174400
-
 predicted from amino acid sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens RNA binding influences the catalytic function of topoisomerase IIalpha to regulate DNA topology, topoisomerase II sequentially interacts with the (G/U)-rich region and poly(A)+ tail of the transcript to regulate the template DNA topology in coordination with transcription termination and poly(A)+ RNA export ?
-
 ?
additional information Homo sapiens topoisomerase IIalpha is a multifunctional enzyme that catalyzes the relaxation of supercoiled DNA, decatenation of interlinked DNA and unknotting of intramolecularly linked DNA by passing a DNA helix through a transient double-strand break in a second helix ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P11388
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RNA binding influences the catalytic function of topoisomerase IIalpha to regulate DNA topology, topoisomerase II sequentially interacts with the (G/U)-rich region and poly(A)+ tail of the transcript to regulate the template DNA topology in coordination with transcription termination and poly(A)+ RNA export Homo sapiens ?
-
 ?
additional information topoisomerase IIalpha is a multifunctional enzyme that catalyzes the relaxation of supercoiled DNA, decatenation of interlinked DNA and unknotting of intramolecularly linked DNA by passing a DNA helix through a transient double-strand break in a second helix Homo sapiens ?
-
 ?
supercoiled DNA + ATP + H2O
-
 Homo sapiens catenated DNA networks + ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
topoisomerase IIalpha
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens