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Literature summary for 5.6.2.2 extracted from
- A new function of Trypanosoma brucei mitochondrial topoisomerase II is to maintain kinetoplast DNA network topology (2008), Mol. Microbiol., 70, 1465-1476.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Trypanosoma brucei | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Trypanosoma brucei | mitochondrial topoisomerase II maintains kinetoplast DNA network topology by constantly remodeling the network during replication to maintain a proper minicircle density and network structure | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma brucei | - |
cell line 29-13 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | mitochondrial topoisomerase II maintains kinetoplast DNA network topology by constantly remodeling the network during replication to maintain a proper minicircle density and network structure | Trypanosoma brucei | ? | - |
? | |
| network of DNA rings + ATP + H2O | - |
Trypanosoma brucei | monomer DNA circles + ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TOP2mt | - |
Trypanosoma brucei |
| Topoisomerase II | - |
Trypanosoma brucei |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Trypanosoma brucei | |
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Release 2023.1 (January 2023)
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