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Literature summary for 5.6.2.2 extracted from

  • Ryckebusch, A.; Garcin, D.; Lansiaux, A.; Goossens, J.F.; Baldeyrou, B.; Houssin, R.; Bailly, C.; Henichart, J.P.
    Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives (2008), J. Med. Chem., 51, 3617-3629.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
2,3-dimethoxy-9-(2-dimethylaminoethoxy)-6-(2-dimethylaminoethyl)-6H-indeno[1,2-c]isoquinolin-5,11-dione
-
 Homo sapiens
2,3-dimethoxy-9-(2-dimethylaminoethoxy)-6-(3-dimethylaminopropyl)-6H-indeno[1,2-c]isoquinolin-5,11-dione
-
 Homo sapiens
3-(2-dimethylaminoethoxy)-6-(2-dimethylaminoethylamino)indeno[2,1-c]quinolin-7-one
-
 Homo sapiens
3-(2-pyrrolidin-1-ylethoxy)-6-(2-pyrrolidin-1-ylethylamino)indeno[2,1-c]quinolin-7-one
-
 Homo sapiens
3-(3-dimethylaminopropoxy)-6-(3-dimethylaminopropylamino)indeno[2,1-c]quinolin-7-one
-
 Homo sapiens
3-hydroxy-6-(2-dimethylaminoethylamino)indeno[2,1-c]quinolin-7-one
-
 Homo sapiens
3-hydroxy-6-(2-pyrrolidin-1-ylethylamino)indeno[2,1-c]quinolin-7-one
-
 Homo sapiens
3-hydroxy-6-(3-dimethylaminopropylamino)indeno[2,1-c]quinolin-7-one
-
 Homo sapiens
6-(2-dimethylaminoethyl)-6H-indeno[1,2-c]isoquinolin-5,11-dione
-
 Homo sapiens
6-(3-dimethylaminopropyl)-6H-indeno[1,2-c]isoquinolin-5,11-dione
-
 Homo sapiens
8-(2-dimethylaminoethoxy)-6-(2-dimethylaminoethyl)-6H-indeno[1,2-c]isoquinolin-5,11-dione
-
 Homo sapiens
8-(2-dimethylaminoethoxy)-6-(3-dimethylaminopropyl)-6Hindeno[1,2-c]isoquinolin-5,11-dione
-
 Homo sapiens
9-(2-dimethylaminoethoxy)-6-(2-dimethylaminoethyl)-6H-indeno[1,2-c]isoquinolin-5,11-dione
-
 Homo sapiens
9-(2-dimethylaminoethoxy)-6-(3-dimethylaminopropyl)-6Hindeno[1,2-c]isoquinolin-5,11-dione
-
 Homo sapiens
9-(2-pyrrolidin-1-ylethoxy)-6-(2-pyrrolidin-1-ylethyl)-6H-indeno[1,2-c]isoquinolin-5,11-dione
-
 Homo sapiens
9-hydroxy-6-(2-dimethylaminoethyl)-6H-indeno[1,2-c]isoquinolin-5,11-dione
-
 Homo sapiens
9-hydroxy-6-(3-dimethylaminopropyl)-6H-indeno[1,2-c]isoquinolin-5,11-dione
-
 Homo sapiens
etoposide
-
 Homo sapiens
MJ-238
-
 Homo sapiens
MJ-III-65
-
 Homo sapiens
NSC727357
-
 Homo sapiens
TAS-103
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-
HL-60/MX-2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA + ATP + H2O
-
 Homo sapiens catenated DNA networks + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Topoisomerase II
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens