Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.2.2 extracted from

  • Goodell, J.R.; Ougolkov, A.V.; Hiasa, H.; Kaur, H.; Remmel, R.; Billadeau, D.D.; Ferguson, D.M.
    Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis (2008), J. Med. Chem., 51, 179-182.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
Aclarubicin catalytic topo II inhibitor Homo sapiens
amsacrine topo II poison Homo sapiens
doxorubicin topo II poison Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BxPC-3 cell
-
 Homo sapiens
-
MiaPaCa-2 cell
-
 Homo sapiens
-
pancreatic cancer cell
-
 Homo sapiens
-
SU.86.86 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA + ATP + H2O
-
 Homo sapiens catenated DNA networks + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
topo II
-
 Homo sapiens
Topoisomerase II
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens