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Literature summary for 5.6.2.2 extracted from

  • Wang, W.; Rupasinghe, S.G.; Schuler, M.A.; Gonzalez de Mejia, E.
    Identification and characterization of topoisomerase II inhibitory peptides from soy protein hydrolysates (2008), J. Agric. Food Chem., 56, 6267-6277.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
FEITPEKNPQ inhibits human topoisomerase II activity through binding to the active site of the CTD domain Homo sapiens
IETWNPNNKP inhibits human topoisomerase II activity through binding to the active site of the CTD domain Homo sapiens
additional information soy protein hydrolysate inhibits 61% of topoisomerase II activity at 0.5 mg/ml Homo sapiens
VFDGEL inhibits human topoisomerase II activity through binding to the active site of the CTD domain Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA + ATP + H2O
-
 Homo sapiens catenated DNA networks + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
topoisomerase IIalpha
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.4
-
 in 50 mM Tris-HCl (pH 8.0) Homo sapiens FEITPEKNPQ
4
-
 in 50 mM Tris-HCl (pH 8.0) Homo sapiens IETWNPNNKP
7.9
-
 in 50 mM Tris-HCl (pH 8.0) Homo sapiens VFDGEL