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Literature summary for 5.6.2.2 extracted from
- Somatostatin elevates topoisomerase II alpha and enhances the cytotoxic effect of doxorubicin on gallbladder cancer cells (2008), Chemotherapy, 54, 431-437.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Somatostatin | elevates topoisomerase II alpha expression | Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| doxorubicin | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gall bladder cancer cell | - |
Homo sapiens | - |
| GBC-SD cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled DNA + ATP + H2O | - |
Homo sapiens | catenated DNA networks + ADP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Topo IIalpha | - |
Homo sapiens |
| topoisomerase II alpha | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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