Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-epigallocatechin gallate | redox-dependent topoisomerase II poison that acts by covalently adducting to the enzyme, inhibits the DNA cleavage activities of topoisomerase IIalpha and beta when incubated with either enzyme prior to the addition of DNA, exposure of (-)-epigallocatechin gallate to dithiothreitol prior to its addition to DNA cleavage assays abrogates the effects of the catechin on DNA scission | Homo sapiens | |
etoposide | - |
Homo sapiens | |
genistein | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
supercoiled DNA + ATP + H2O | - |
Homo sapiens | catenated DNA networks + ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
topoisomerase IIalpha | isoform | Homo sapiens |
topoisomerase IIbeta | isoform | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |