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Literature summary for 5.6.2.2 extracted from

  • Terry, S.Y.; Riches, A.C.; Bryant, P.E.
    A role for topoisomerase II alpha in the formation of radiation-induced chromatid breaks (2008), Br. J. Cancer, 99, 670-674.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens indirect involvement of topoisomerase II alpha in the formation of radiation-induced chromatid breaks from DNA double-strand breaks, topoisomerase II alpha is a possible factor in the inter-individual variation in chromatid radiosensitivity ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
Homo sapiens
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HL-60/MX-2 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information indirect involvement of topoisomerase II alpha in the formation of radiation-induced chromatid breaks from DNA double-strand breaks, topoisomerase II alpha is a possible factor in the inter-individual variation in chromatid radiosensitivity Homo sapiens ?
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?
supercoiled DNA + ATP + H2O
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Homo sapiens catenated DNA networks + ADP + phosphate
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?

Synonyms

Synonyms Comment Organism
topoisomerase II alpha isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens