Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.2.2 extracted from

  • Cortazar, T.M.; Coombs, G.H.; Walker, J.
    Leishmania panamensis: comparative inhibition of nuclear DNA topoisomerase II enzymes from promastigotes and human macrophages reveals anti-parasite selectivity of fluoroquinolones, flavonoids and pentamidine (2007), Exp. Parasitol., 116, 475-482.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
Ciprofloxacin 40fold higher selectivity for Leishmania panamensis enzyme over human macrophage enzyme Homo sapiens
Ciprofloxacin 40fold higher selectivity for Leishmania panamensis enzyme over human macrophage enzyme Leishmania panamensis
coralyne potent inhibitor of both human and leishmania panamensis enzyme Homo sapiens
coralyne potent inhibitor of both human and leishmania panamensis enzyme Leishmania panamensis
ellagic acid 15.7fold higher selectivity human macrophage for enzyme over Leishmania panamensis enzyme Homo sapiens
ellagic acid 15.7fold higher selectivity human macrophage for enzyme over Leishmania panamensis enzyme Leishmania panamensis
enoxacin 592fold higher selelctivity for Leishmania panamensis enzyme over human macrophage enzyme Homo sapiens
enoxacin 592fold higher selelctivity for Leishmania panamensis enzyme over human macrophage enzyme Leishmania panamensis
Pentamidine 17.6fold higher selectivity for Leishmania panamensis enzyme over human macrophage enzyme Homo sapiens
Pentamidine 17.6fold higher selectivity for Leishmania panamensis enzyme over human macrophage enzyme Leishmania panamensis
quercetin 161fold higher selectivity for Leishmania panamensis enzyme over human macrophage enzyme Homo sapiens
quercetin 161fold higher selectivity for Leishmania panamensis enzyme over human macrophage enzyme Leishmania panamensis

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Leishmania panamensis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0006
-
 pH 8.0, 37°C Leishmania panamensis quercetin
0.0026
-
 pH 8.0, 37°C Leishmania panamensis enoxacin
0.0263
-
 pH 8.0, 37°C Homo sapiens ellagic acid
0.0329
-
 pH 8.0, 37°C Leishmania panamensis coralyne
0.05
-
 pH 8.0, 37°C Leishmania panamensis Ciprofloxacin
0.074
-
 pH 8.0, 37°C Homo sapiens coralyne
0.0811
-
 pH 8.0, 37°C Leishmania panamensis Pentamidine
0.0889
-
 pH 8.0, 37°C Homo sapiens quercetin
0.413
-
 pH 8.0, 37°C Leishmania panamensis ellagic acid
1.426
-
 pH 8.0, 37°C Homo sapiens Pentamidine
1.485
-
 pH 8.0, 37°C Homo sapiens enoxacin
1.999
-
 pH 8.0, 37°C Homo sapiens Ciprofloxacin