Protein Variants | Comment | Organism |
---|---|---|
C455A | mutant is 1.5fold more sensitive to 1,4-benzoquinone and 2-(4-chlorophenyl)benzo-1,4-quinone, but shows wild-type sensitivity to traditional topoisomerase II poisons | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-benzoquinone | inhibition by blocking the N-terminal gate of enzyme | Homo sapiens | |
2-(4-chlorophenyl)benzo-1,4-quinone | inhibition by blocking the N-terminal gate of enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform topoisomerase IIalpha | - |