Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aclacinomycin A | - |
Homo sapiens | |
bis(acridin-4-ylmethyl)cyanamide | comparison with inhibition of calpain, chymotrypsin, cathepsin B, trypsin | Homo sapiens | |
Mitoxantrone | - |
Homo sapiens | |
N,N,N',N'-tetrakis(acridin-4-ylmethyl)butane-1,4-diamine | compound shows in addition in vitro proteasome inhibition properties. Comparison with inhibition of calpain, chymotrypsin, cathepsin B, trypsin | Homo sapiens | |
N,N,N',N'-tetrakis(acridin-4-ylmethyl)ethane-1,2-diamine | comparison with inhibition of calpain, chymotrypsin, cathepsin B, trypsin | Homo sapiens | |
N,N,N',N'-tetrakis[(7-bromo-9-chloroacridin-4-yl)methyl]butane-1,4-diamine | comparison with inhibition of calpain, chymotrypsin, cathepsin B, trypsin | Homo sapiens | |
N,N,N',N'-tetrakis[(9-aminoacridin-4-yl)methyl]ethane-1,2-diamine | compound shows in addition in vitro proteasome inhibition properties. Comparison with inhibition of calpain, chymotrypsin, cathepsin B, trypsin | Homo sapiens | |
N-(acridin-1-ylmethyl)-N,N',N'-tris(acridin-2-ylmethyl)octane-1,8-diamine | comparison with inhibition of calpain, chymotrypsin, cathepsin B, trypsin | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
recombinant enzyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | sensitive to topoisomerase II inhibitors | Homo sapiens | - |
HL60/MX2 cell | resitant to topoisomerase II inhibitors | Homo sapiens | - |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0002 | - |
pH 8.0 | Homo sapiens | N,N,N',N'-tetrakis[(7-bromo-9-chloroacridin-4-yl)methyl]butane-1,4-diamine | |
0.0004 | - |
pH 8.0 | Homo sapiens | N-(acridin-1-ylmethyl)-N,N',N'-tris(acridin-2-ylmethyl)octane-1,8-diamine | |
0.0009 | - |
pH 8.0 | Homo sapiens | N,N,N',N'-tetrakis[(9-aminoacridin-4-yl)methyl]ethane-1,2-diamine | |
0.002 | - |
- |
Homo sapiens | Mitoxantrone | |
0.002 | - |
- |
Homo sapiens | aclacinomycin A | |
0.0043 | - |
pH 8.0 | Homo sapiens | N,N,N',N'-tetrakis(acridin-4-ylmethyl)butane-1,4-diamine | |
0.0057 | - |
pH 8.0 | Homo sapiens | N,N,N',N'-tetrakis(acridin-4-ylmethyl)ethane-1,2-diamine | |
0.0065 | - |
pH 8.0 | Homo sapiens | bis(acridin-4-ylmethyl)cyanamide |