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Literature summary for 5.6.2.2 extracted from

  • Montaner, B.; Castillo-Avila, W.; Martinell, M.; Ollinger, R.; Aymami, J.; Giralt, E.; Perez-Tomas, R.
    DNA interaction and dual topoisomerase I and II inhibition properties of the anti-tumor drug prodigiosin (2005), Toxicol. Sci., 85, 870-879.
    View publication on PubMed
Search for more literature for 5.6.2.2

Application

Application Comment Organism
pharmacology the enzyme is a therapeutic target for the anti-tumor drug prodigiosin Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
prodigiosin red pigment of Serratia marcescens with apoptotic activity, anti-tumor drug, induces Cu2+-mediated pH-dependent DNA damage, inhibits the enzyme in vitro and in vivo by binding and intercalation with the DNA Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
KCl
-
 Homo sapiens
Mg2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled pRYG DNA + ATP + H2O cleavage of supercoiled pRYG DNA Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
toposiomerase II
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens