Literature summary for 5.6.2.2 extracted from

Zhou, Z.; Guan, H.; Kleinerman, E.S.
E1A specifically enhances sensitivity to topoisomerase IIa targeting anticancer drug by up-regulating the promoter activity (2005), Mol. Cancer Res., 3, 271-275.

Search for more literature for 5.6.2.2

Activating Compound

Activating Compound	Comment	Organism	Structure
E1A	an adenovirus type 5-based vector that contains E1A, but lacks E1B and E3, specifically enhances the promoter activity by 3.5fold, which leads to increased enzyme expression, overview	Homo sapiens

Application

Application	Comment	Organism
pharmacology	combining topoisomerase II targeting anticancer drug therapy with E1A vector gene therapy might increase the tumor cell sensitivity and thus the therapeutic benefit	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	transfection of TC71 cells with E1A, an adenovirus type 5-based vector that contains E1A, but lacks E1B and E3, specifically enhances sensitivity of topoisomerase IIa for anticancer drugs by up-regulating the promoter activity by 3.5fold	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
adriamycin	enzyme targeting anticancer drug, inhibits in vitro and in vivo, inhibition is 8fold increased by cell transfection with the E1A vector	Homo sapiens
etoposide	i.e. VP-16, enzyme targeting anticancer drug, inhibits in vitro and in vivo, inhibition is 16fold increased by cell transfection with the E1A vector	Homo sapiens
additional information	E1A, an adenovirus type 5-based vector that contains E1A, but lacks E1B and E3, specifically enhances sensitivity to topoisomerase IIa targeting anticancer drugs etoposide and adriamycin, but not to amsacrine and camptothecin, by up-regulating the promoter activity by 3.5fold, which also leads to increased enzyme expression, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Ewing's sarcoma cell	-	Homo sapiens	-
TC-71 cell	Ewing's sarcoma cell line	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Topoisomerase II	-	Homo sapiens

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Release 2023.1 (January 2023)