Literature summary for 5.6.2.2 extracted from

Christmann-Franck, S.; Bertrand, H.O.; Goupil-Lamy, A.; der Garabedian, P.A.; Mauffret, O.; Hoffmann, R.; Fermandjian, S.
Structure-based virtual screening: an application to human topoisomerase II alpha (2004), J. Med. Chem., 47, 6840-6853.

Cloned(Commentary)

Cloned (Comment)	Organism
enzyme DNA sequence analysis	Homo sapiens

Inhibitors	Comment	Organism
A-132	-	Homo sapiens
Aclarubicin	i.e. NCI0654508	Homo sapiens
BBR-3438	-	Homo sapiens
chartreusin	-	Homo sapiens
chromomycin A3	-	Homo sapiens
detorubicin	-	Homo sapiens
distel (1+)	-	Homo sapiens
elsamicin A	-	Homo sapiens
KW2170	-	Homo sapiens
marcellomycin	-	Homo sapiens
mithramycin	-	Homo sapiens
additional information	combination of molecular modeling and virtual screening for inhibitor identification, structural features for inhibitory effect on the enzyme, inhibitory mechanisms, overview	Homo sapiens
NC-182	-	Homo sapiens
NCI0007535	-	Homo sapiens
NCI0009223	-	Homo sapiens
NCI0107678	-	Homo sapiens
NCI0245021	-	Homo sapiens
NCI0402956	-	Homo sapiens
NCI0603831	-	Homo sapiens
NCI0694885	-	Homo sapiens
piroxantrone	-	Homo sapiens
teloxantrone	-	Homo sapiens
valrubicin	-	Homo sapiens
variamycin	-	Homo sapiens

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	P11388	-	-

Reaction	Comment	Organism	Reaction ID
ATP-dependent breakage, passage and rejoining of double-stranded DNA	catalytic residue is Y815, active site structure includes residues Q789, D799, A801, S802, R804, and Y805	Homo sapiens	a

Subunits	Comment	Organism
dimer	-	Homo sapiens

Synonyms	Comment	Organism
topoisomerase II alpha	-	Homo sapiens

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at, relaxation assay	Homo sapiens

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at, relaxation assay	Homo sapiens

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens