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Literature summary for 5.6.2.2 extracted from

  • Dickey, J.S.; Choi, T.J.; Van Etten, J.L.; Osheroff, N.
    Chlorella virus Marburg topoisomerase II: high DNA cleavage activity as a characteristic of Chlorella virus type II enzymes (2005), Biochemistry, 44, 3899-3908.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
amsacrine weak activation of DNA cleavage at some sites Chlorella virus Marburg
etoposide weak activation of DNA cleavage at some sites Chlorella virus Marburg

Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae strain JEL-1DELTAtop1 Chlorella virus Marburg
expression in Saccharomyces cerevisiae strain JEL-1DELTAtop1 Paramecium bursaria chlorella virus

Inhibitors

Inhibitors Comment Organism Structure
amsacrine weak inhibition of DNA cleavage at some sites, primarily inhibition of DNA ligation, low sensitivity for the drug Chlorella virus Marburg
CP-115953
-
Chlorella virus Marburg
EDTA
-
Chlorella virus Marburg
EDTA
-
Paramecium bursaria chlorella virus
etoposide weak inhibition of DNA cleavage at some sites, primarily inhibition of DNA ligation, low sensitivity for the drug Chlorella virus Marburg

Metals/Ions

Metals/Ions Comment Organism Structure
KCl
-
Chlorella virus Marburg
KCl
-
Paramecium bursaria chlorella virus
Mg2+ required for cleavage Chlorella virus Marburg
Mg2+ required for cleavage Paramecium bursaria chlorella virus
NaCl
-
Paramecium bursaria chlorella virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dsDNA + ATP + H2O Paramecium bursaria chlorella virus breakage, passage, decatenation, and rejoining of dsDNA, enzyme is required for conrol of DNA topology ?
-
?
dsDNA + ATP + H2O Chlorella virus Marburg breakage, passage, decatenation, and rejoining of dsDNA, enzyme is required for control of DNA topology ?
-
?

Organism

Organism UniProt Comment Textmining
Chlorella virus Marburg
-
i.e. CVM-1
-
Paramecium bursaria chlorella virus
-
i.e. PBCV-1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dsDNA + ATP + H2O breakage, passage, decatenation, and rejoining of dsDNA, enzyme is required for conrol of DNA topology Paramecium bursaria chlorella virus ?
-
?
dsDNA + ATP + H2O breakage, passage, decatenation, and rejoining of dsDNA, enzyme is required for control of DNA topology Chlorella virus Marburg ?
-
?
dsDNA + ATP + H2O breakage, passage, decatenation, and rejoining of dsDNA, very high DNA cleavage activity and high strand passage activity of the viral type enzyme, tight DNA binding, mapping of DNA cleavage sites Chlorella virus Marburg ?
-
?
dsDNA + ATP + H2O breakage, passage, decatenation, and rejoining of dsDNA, very high DNA cleavage activity of the viral type enzyme, mapping of DNA cleavage sites Paramecium bursaria chlorella virus ?
-
?
kinetoplast DNA + ATP + H2O breakage, passage, decatenation, and rejoining of kinetoplast DNA, kinetoplast DNA is isolated from Crithidia fasciculata Chlorella virus Marburg ?
-
?
additional information formation of a covalent enzyme-DNA complex is a prerequisite for activity, the intermediate can destabilize the genome Chlorella virus Marburg ?
-
?
additional information formation of a covalent enzyme-DNA complex is a prerequisite for activity, the intermediate can destabilize the genome Paramecium bursaria chlorella virus ?
-
?
negatively supercoiled pBR322 DNA + ATP + H2O breakage, passage, and rejoining of negatively supercoiled pBR322 DNA Paramecium bursaria chlorella virus ?
-
?
negatively supercoiled pBR322 DNA + ATP + H2O breakage, passage, decatenation, and rejoining of negatively supercoiled pBR322 DNA Chlorella virus Marburg ?
-
?

Synonyms

Synonyms Comment Organism
Topoisomerase II
-
Chlorella virus Marburg
Topoisomerase II
-
Paramecium bursaria chlorella virus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Paramecium bursaria chlorella virus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
30
-
assay at Chlorella virus Marburg

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
assay at Chlorella virus Marburg
8.5
-
assay at Paramecium bursaria chlorella virus

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Paramecium bursaria chlorella virus
ATP dependent on, required for DNA relaxation and decatenation Chlorella virus Marburg