Literature summary for 5.6.2.2 extracted from

Wada, S.I.; Iida, A.; Tanaka, R.
Triterpene constituents from the stem bark of Pinus luchuensis and their DNA topoisomerase II inhibitory effect (2001), Planta Med., 67, 659-664.

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Inhibitors

Inhibitors	Comment	Organism	Structure
25,26,27-tris-nor-3beta-methoxylanost-9(11)-en-24-oic acid	-	Homo sapiens
3-oxolanost-9(11)-ene-24S,25-diol	IC50: 0.186 mM	Homo sapiens
etoposide	IC50: 0.05 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
supercoiled plasmid DNA + ATP + H2O	-	Homo sapiens	relaxed DNA + ADP + phosphate	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.05	-	IC50: 0.05 mM	Homo sapiens	etoposide
0.186	-	IC50: 0.186 mM	Homo sapiens	3-oxolanost-9(11)-ene-24S,25-diol

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Release 2023.1 (January 2023)