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Literature summary for 5.6.2.2 extracted from

  • Skouboe, C.; Bjergbaek, L.; Oestergaard, V.H.; Larsen, M.K.; Knudsen, B.R.; Andersen, A.H.
    A Human topoisomerase IIa heterodimer with only one ATP binding site can go through successive catalytic cycles (2003), J. Biol. Chem., 278, 5768-5774.
    View publication on PubMed
Search for more literature for 5.6.2.2

Protein Variants

Protein Variants Comment Organism
additional information a heterodimer with only one ATP binding site is able to relax supercoiled DNA, although less efficiently than the wild-type enzyme. The heterodimer lacks the normal stimulatory effect of DNA on ATP binding and hydrolysis as well as the stimulatory effect of ATP and DNA cleavage Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is essential for DNA metabolism and chromosome dynamics. It changes the topology of DNA by coupling binding and hydrolysis of two ATP molecules to the transport of one DNA duplex through a temporary break introduced in another ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information changes the topology of DNA by coupling binding and hydrolysis of two ATP molecules to the transport of one DNA duplex through a temporary break introduced in another Homo sapiens ?
-
 ?
additional information the enzyme is essential for DNA metabolism and chromosome dynamics. It changes the topology of DNA by coupling binding and hydrolysis of two ATP molecules to the transport of one DNA duplex through a temporary break introduced in another Homo sapiens ?
-
 ?