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Literature summary for 5.6.2.2 extracted from
- The p53 tumor suppressor stimulates the catalytic activity of human topoisomerase IIa by enhancing the rate of ATP hydrolysis (2000), J. Biol. Chem., 275, 18503-18510.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| p53 tumor suppressor | stimulates the catalytic activity by enhancing the rate of ATP hydrolysis | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
topoisomerase IIalpha | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kinetoplast DNA + ATP | decatenation | Homo sapiens | ? | - |
? |  |
| negatively supercoiled DNA + ATP + H2O | relaxation | Homo sapiens | ? | - |
? | |
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