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Literature summary for 5.6.2.2 extracted from
- Novel mechanisms of DNA topoisomerase II inhibition by pyranonaphthoquinone derivatives-eleutherin, alpha lapachone, and beta lapachone (2000), Biochem. Pharmacol., 60, 1367-1379.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-lapachone | inhibits initial non-covalent binding of topoisomerase II to DNA and, in addition, induces religation of DNA breaks, irreversible | Homo sapiens |  |
| beta-lapachone | inhibits by inducing religation and dissociation of the enzyme from DNA in presence of ATP, irreversible | Homo sapiens | |
| eleutherin | inhibits by inducing religation and dissociation of the enzyme from DNA in presence of ATP | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled pBR322 + ATP | relaxation | Homo sapiens | ? | - |
? | |
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