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Literature summary for 5.6.2.2 extracted from
- Inhibition of DNA topoisomerase II catalytic activity by the antiviral agents 7-chloro-1,3-dihydroxyacridone and 1,3,7-trihydroxyacridone (1999), Biochem. Pharmacol., 58, 703-708.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 7-chloro-1,3-dihydroxyacridone | at both 0.2 mM and 0.1 mM, preincubation with the enzyme prior to the addition of DNA leads to the complete loss of DNA binding | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled plasmid pBR322 DNA + ATP | relaxation of supercoiled DNA | Homo sapiens | ? | - |
? | |
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