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Literature summary for 5.6.2.2 extracted from
- A new topoisomerase-II inhibitor, BE-10988, produced by a streptomycete. I. Taxonomy, fermentation, isolation and characterization (1991), J. Antibiot., 44, 486-491.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BE-10988 | the inhibitor is produced by a streptomycete | Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| P-388 cell | vincristine-resistant line and vincristine-sensitive line | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| network of DNA rings + ATP + H2O | decatenation | Mus musculus | monomeric DNA circles + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Mus musculus | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Mus musculus | relaxed DNA + ADP + phosphate | - |
? | |
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