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Literature summary for 5.6.2.2 extracted from
- Yeast topoisomerase II mutants resistant to anti-topoisomerase agents: identification and characterization of new yeast topoisomerase II mutants selected for resistance to etoposide (1994), Cancer Res., 54, 2943-2951.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | two mutants resistant to etoposide and amsacrine, and a third mutant partially resistant to etoposide and fluoroquinoline but not the amsacrine, that has an amino acid change at position 738 | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| network of DNA rings + ATP + H2O | decatenation | Saccharomyces cerevisiae | monomeric DNA circles + ADP + phosphate | - |
? |  |
| supercoiled DNA + ATP + H2O | catenation | Saccharomyces cerevisiae | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Saccharomyces cerevisiae | relaxed DNA + ADP + phosphate | - |
? | |
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Release 2023.1 (January 2023)
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