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Literature summary for 5.6.2.2 extracted from

  • Douc-Rasy, S.; Kayser, A.; Riou, J.F.; Riou, G.
    ATP-independent type II topoisomerase from trypanosomes (1986), Proc. Natl. Acad. Sci. USA, 83, 7152-7156.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Berenil
-
Trypanosoma cruzi
Clorobiocin
-
Trypanosoma cruzi
coumermycin coumermycin A2 Trypanosoma cruzi
ellipticines
-
Trypanosoma cruzi
Hydroxystilbamidine
-
Trypanosoma cruzi
KCl above 50 mM Trypanosoma cruzi
NaCl above 50 mM Trypanosoma cruzi

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ can substitute for Mg2+ Trypanosoma cruzi
K+ required Trypanosoma cruzi
Mg2+ required Trypanosoma cruzi
Mn2+ can substitute for Mg2+ Trypanosoma cruzi

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
200000
-
sedimentation equilibrium centrifugation Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Trypanosoma cruzi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme can alter the linking number of DNA only in steps of two Trypanosoma cruzi ?
-
?
additional information unknotting activity Trypanosoma cruzi ?
-
?
additional information no ATPase activity Trypanosoma cruzi ?
-
?
network of DNA rings + ATP + H2O decatenation Trypanosoma cruzi monomeric DNA circles + ADP + phosphate
-
?
supercoiled DNA + ATP + H2O catenation Trypanosoma cruzi catenated DNA networks + ADP + phosphate
-
?
supercoiled DNA + ATP + H2O catenation in absence of ATP Trypanosoma cruzi catenated DNA networks + ADP + phosphate
-
?
supercoiled DNA + ATP + H2O relaxation Trypanosoma cruzi relaxed DNA + ADP + phosphate
-
?