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Literature summary for 5.6.2.2 extracted from

  • Arndt-Jovin, D.J.; Udvardy, A.; Garner, M.M.; Ritter, S.; Jovin, T.M.
    Z-DNA binding and inhibition of GTP of Drosophila topoisomerase II (1993), Biochemistry, 32, 4862-4872.
    View publication on PubMed
Search for more literature for 5.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
GTP allosteric inhibition Drosophila melanogaster
GTP-gamma-S allosteric inhibition Drosophila melanogaster
Z-DNA inhibits relaxation of closed circular supercoiled DNA Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Drosophila melanogaster the Z-DNA binding activity of undegraded topoisomerase II may be important in targeting the enzyme both to structural motifs required for chromatin organization and to sites of local supercoiling ?
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 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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-
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Source Tissue

Source Tissue Comment Organism Textmining
embryo
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 Drosophila melanogaster
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tissue culture
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 Drosophila melanogaster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme binds Z-DNA with an affinity 2 orders of magnitude greater than that for B-DNA Drosophila melanogaster ?
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 ?
additional information the Z-DNA binding activity of undegraded topoisomerase II may be important in targeting the enzyme both to structural motifs required for chromatin organization and to sites of local supercoiling Drosophila melanogaster ?
-
 ?
network of DNA rings + ATP + H2O decatenation Drosophila melanogaster monomeric DNA circles + ADP + phosphate
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 ?
supercoiled DNA + ATP + H2O catenation Drosophila melanogaster catenated DNA networks + ADP + phosphate
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 ?
supercoiled DNA + ATP + H2O relaxation Drosophila melanogaster relaxed DNA + ADP + phosphate
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 ?