Any feedback?
Literature summary for 5.6.2.2 extracted from
- Evolution of the ATP recognition site of DNA topoisomerases II. Design of new inhibitors (1997), Lett. Pept. Sci., 4, 403-406.
No PubMed abstract available
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bos taurus | enzyme is required for chromosome segregation | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP-dependent breakage, passage and rejoining of double-stranded DNA | enzyme is involved in the chromosome segregation that occurs at the end of the DNA replication | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| thymus | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | dATP can substitute for ATP. 8-Azidoadenosine 5'-triphosphate is used less efficiently by the enzyme than ATP | Bos taurus | ? | - |
? | |
| additional information | enzyme is required for chromosome segregation | Bos taurus | ? | - |
? | |
| network of DNA rings + ATP + H2O | decatenation | Bos taurus | monomeric DNA circles + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Bos taurus | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Bos taurus | relaxed DNA + ADP + phosphate | - |
? | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
