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Literature summary for 5.6.2.2 extracted from

  • Knudsen, B.R.; Straub, T.; Boege, F.
    Separation and functional analysis of eukaryotic DNA topoisomerases by chromatography and electrophoresis (1996), J. Chromatogr., 684, 307-321.
    View publication on PubMed

Application

Application Comment Organism
pharmacology important cellular target in the treatment of human cancers eukaryota

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bacteria
-
?
-
?
additional information eukaryota controls DNA topology by cleaving and rejoining DNA strands and passing other DNA strands through transient gaps. Plays a crucial function in the regulation of the physiological function of the genome ?
-
?

Organism

Organism UniProt Comment Textmining
Bacteria
-
-
-
eukaryota
-
-
-
Mammalia
-
two structurally related isoforms
-

Purification (Commentary)

Purification (Comment) Organism
general purification strategy eukaryota

Source Tissue

Source Tissue Comment Organism Textmining
additional information expression of topoisomerase II is proliferation-dependent and alters during the cell cycle eukaryota
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
Bacteria ?
-
?
additional information controls DNA topology by cleaving and rejoining DNA strands and passing other DNA strands through transient gaps. Plays a crucial function in the regulation of the physiological function of the genome eukaryota ?
-
?
network of DNA rings + ATP + H2O decatenation Mammalia monomeric DNA circles + ADP + phosphate
-
?
network of DNA rings + ATP + H2O decatenation Bacteria monomeric DNA circles + ADP + phosphate
-
?
network of DNA rings + ATP + H2O decatenation eukaryota monomeric DNA circles + ADP + phosphate
-
?
supercoiled DNA + ATP + H2O catenation Mammalia catenated DNA networks + ADP + phosphate
-
?
supercoiled DNA + ATP + H2O catenation Bacteria catenated DNA networks + ADP + phosphate
-
?
supercoiled DNA + ATP + H2O catenation eukaryota catenated DNA networks + ADP + phosphate
-
?
supercoiled DNA + ATP + H2O relaxation Mammalia relaxed DNA + ADP + phosphate
-
?
supercoiled DNA + ATP + H2O relaxation Bacteria relaxed DNA + ADP + phosphate
-
?
supercoiled DNA + ATP + H2O relaxation eukaryota relaxed DNA + ADP + phosphate
-
?

Subunits

Subunits Comment Organism
dimer dimer of identical subunits eukaryota