Application | Comment | Organism |
---|---|---|
pharmacology | important cellular target in the treatment of human cancers | eukaryota |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bacteria | - |
? | - |
? | |
additional information | eukaryota | controls DNA topology by cleaving and rejoining DNA strands and passing other DNA strands through transient gaps. Plays a crucial function in the regulation of the physiological function of the genome | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacteria | - |
- |
- |
eukaryota | - |
- |
- |
Mammalia | - |
two structurally related isoforms | - |
Purification (Comment) | Organism |
---|---|
general purification strategy | eukaryota |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | expression of topoisomerase II is proliferation-dependent and alters during the cell cycle | eukaryota | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | - |
Bacteria | ? | - |
? | |
additional information | controls DNA topology by cleaving and rejoining DNA strands and passing other DNA strands through transient gaps. Plays a crucial function in the regulation of the physiological function of the genome | eukaryota | ? | - |
? | |
network of DNA rings + ATP + H2O | decatenation | Mammalia | monomeric DNA circles + ADP + phosphate | - |
? | |
network of DNA rings + ATP + H2O | decatenation | Bacteria | monomeric DNA circles + ADP + phosphate | - |
? | |
network of DNA rings + ATP + H2O | decatenation | eukaryota | monomeric DNA circles + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | catenation | Mammalia | catenated DNA networks + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | catenation | Bacteria | catenated DNA networks + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | catenation | eukaryota | catenated DNA networks + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | relaxation | Mammalia | relaxed DNA + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | relaxation | Bacteria | relaxed DNA + ADP + phosphate | - |
? | |
supercoiled DNA + ATP + H2O | relaxation | eukaryota | relaxed DNA + ADP + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | dimer of identical subunits | eukaryota |