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Literature summary for 5.6.2.2 extracted from
- DNA topoisomerases (1981), Annu. Rev. Biochem., 50, 879-910.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (beta,gamma-Imido)adenosine triphosphate | inhibits ATP-driven supercoiling | eukaryota |  |
| coumermycin | coumermycin A1 | Bacillus subtilis | |
| coumermycin | coumermycin A1 | Escherichia coli | |
| coumermycin | coumermycin A1 | eukaryota | |
| coumermycin | coumermycin A1 | Micrococcus luteus | |
| Nalidixic acid | - |
Bacillus subtilis | |
| Nalidixic acid | - |
Escherichia coli | |
| Nalidixic acid | - |
eukaryota | |
| Nalidixic acid | - |
Micrococcus luteus | |
| novobiocin | no inhibition | Escherichia coli | |
| novobiocin | no inhibition | eukaryota | |
| novobiocin | no inhibition | Rattus norvegicus | |
| Oxolinic acid | - |
Bacillus subtilis | |
| Oxolinic acid | - |
Escherichia coli | |
| Oxolinic acid | - |
eukaryota | |
| Oxolinic acid | - |
Micrococcus luteus | |
| Oxolinic acid | little or no inhibition | Tequatrovirus T4 | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 97000 | - |
2 * 97000 + 2 * 115000 | Micrococcus luteus |
| 115000 | - |
2 * 97000 + 2 * 115000 | Micrococcus luteus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | - |
? | - |
? | |
| additional information | Bos taurus | - |
? | - |
? | |
| additional information | Bacteria | biological role of topoisomerase II and DNA gyrase | ? | - |
? | |
| additional information | eukaryota | biological role of topoisomerase II and DNA gyrase | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Bacteria | - |
- |
- |
| Bos taurus | - |
calf | - |
| Escherichia coli | - |
- |
- |
| eukaryota | - |
- |
- |
| Micrococcus luteus | - |
- |
- |
| Pseudomonas aeruginosa | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Tequatrovirus T4 | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | E. coli, bacteriophage T4-infected | Tequatrovirus T4 | - |
| thymus | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | - |
eukaryota | ? | - |
? | |
| additional information | - |
Rattus norvegicus | ? | - |
? | |
| additional information | - |
Bos taurus | ? | - |
? | |
| additional information | DNA-dependent ATPase activity | Tequatrovirus T4 | ? | - |
? | |
| additional information | the linking number of a DNA molecule changes by one to two units for each ATP molecule hydrolyzed | Tequatrovirus T4 | ? | - |
? | |
| additional information | ATP-dependent negative supercoiling of closed circular duplex DNA | Escherichia coli | ? | - |
? | |
| additional information | when large amounts of enzyme are incubated with circular duplex DNA in absence of ATP, knotted molecules of varying complexity are formed | Tequatrovirus T4 | ? | - |
? | |
| additional information | dATP can substitute for ATP in the supercoiling reaction | Escherichia coli | ? | - |
? | |
| additional information | biological role of topoisomerase II and DNA gyrase | Bacteria | ? | - |
? | |
| additional information | biological role of topoisomerase II and DNA gyrase | eukaryota | ? | - |
? | |
| network of DNA rings + ATP + H2O | decatenation | Bacteria | monomeric DNA circles + ADP + phosphate | - |
? | |
| network of DNA rings + ATP + H2O | decatenation | eukaryota | monomeric DNA circles + ADP + phosphate | - |
? | |
| network of DNA rings + ATP + H2O | decatenation | Bacillus subtilis | monomeric DNA circles + ADP + phosphate | - |
? | |
| network of DNA rings + ATP + H2O | decatenation | Escherichia coli | monomeric DNA circles + ADP + phosphate | - |
? | |
| network of DNA rings + ATP + H2O | decatenation | Rattus norvegicus | monomeric DNA circles + ADP + phosphate | - |
? | |
| network of DNA rings + ATP + H2O | decatenation | Bos taurus | monomeric DNA circles + ADP + phosphate | - |
? | |
| network of DNA rings + ATP + H2O | decatenation | Pseudomonas aeruginosa | monomeric DNA circles + ADP + phosphate | - |
? | |
| network of DNA rings + ATP + H2O | decatenation | Micrococcus luteus | monomeric DNA circles + ADP + phosphate | - |
? | |
| network of DNA rings + ATP + H2O | decatenation | Tequatrovirus T4 | monomeric DNA circles + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Bacteria | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | eukaryota | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Bacillus subtilis | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Escherichia coli | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Rattus norvegicus | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Bos taurus | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Pseudomonas aeruginosa | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Micrococcus luteus | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Tequatrovirus T4 | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Bacteria | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | eukaryota | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Bacillus subtilis | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Escherichia coli | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Rattus norvegicus | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Bos taurus | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Pseudomonas aeruginosa | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Micrococcus luteus | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Tequatrovirus T4 | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation of negatively or positively supercoiled DNA | eukaryota | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation of negatively or positively supercoiled DNA | Escherichia coli | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation of negatively or positively supercoiled DNA | Bos taurus | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation of negatively or positively supercoiled DNA | Tequatrovirus T4 | relaxed DNA + ADP + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | - |
Bacillus subtilis |
| tetramer | - |
Escherichia coli |
| tetramer | - |
Pseudomonas aeruginosa |
| tetramer | 2 * 97000 + 2 * 115000 | Micrococcus luteus |
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