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Literature summary for 5.6.2.2 extracted from
- Inhibitors of trypanosome topoisomerases (1986), Biochem. Soc. Trans., 14, 496-499.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Clorobiocin | - |
Trypanosoma cruzi |  |
| Clorobiocin | - |
Trypanosoma equiperdum | |
| coumermycin | coumermycin A2 | Trypanosoma cruzi | |
| coumermycin | coumermycin A2 | Trypanosoma equiperdum | |
| Hydroxystilbamidine | - |
Trypanosoma cruzi | |
| Hydroxystilbamidine | - |
Trypanosoma equiperdum | |
| Lampit | - |
Trypanosoma cruzi | |
| Lampit | - |
Trypanosoma equiperdum | |
| novobiocin | - |
Trypanosoma cruzi | |
| novobiocin | - |
Trypanosoma equiperdum | |
| Pefloxacin | - |
Trypanosoma cruzi | |
| Pefloxacin | - |
Trypanosoma equiperdum | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | required | Trypanosoma cruzi | |
| K+ | required | Trypanosoma equiperdum | |
| Mg2+ | required | Trypanosoma cruzi | |
| Mg2+ | required | Trypanosoma equiperdum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma cruzi | - |
- |
- |
| Trypanosoma equiperdum | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| network of DNA rings + ATP + H2O | decatenation of kDNA networks | Trypanosoma cruzi | monomeric DNA circles + ADP + phosphate | - |
? | |
| network of DNA rings + ATP + H2O | decatenation of kDNA networks | Trypanosoma equiperdum | monomeric DNA circles + ADP + phosphate | - |
? | |
| network of DNA rings + ATP + H2O | decatenation | Trypanosoma cruzi | monomeric DNA circles + ADP + phosphate | - |
? | |
| network of DNA rings + ATP + H2O | decatenation | Trypanosoma equiperdum | monomeric DNA circles + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Trypanosoma cruzi | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | catenation | Trypanosoma equiperdum | catenated DNA networks + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Trypanosoma cruzi | relaxed DNA + ADP + phosphate | - |
? | |
| supercoiled DNA + ATP + H2O | relaxation | Trypanosoma equiperdum | relaxed DNA + ADP + phosphate | - |
? | |
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