Literature summary for 5.6.2.1 extracted from

Sirikantaramas, S.; Meeprasert, A.; Rungrotmongkol, T.; Fuji, H.; Hoshino, T.; Sudo, H.; Yamazaki, M.; Saito, K.
Structural insight of DNA topoisomerases I from camptothecin-producing plants revealed by molecular dynamics simulations (2015), Phytochemistry, 113, 50-56 .

Search for more literature for 5.6.2.1

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Saccharomyces cerevisiae strain RS190	Ophiorrhiza pumila
expressed in Saccharomyces cerevisiae strain RS190	Nothapodytes nimmoniana
expressed in Saccharomyces cerevisiae strain RS190	Camptotheca acuminata

Protein Variants

Protein Variants	Comment	Organism
D710G	the mutant is resistant against topotecan	Ophiorrhiza pumila
V617G	the mutant is resistant against topotecan	Camptotheca acuminata

Inhibitors

Inhibitors	Comment	Organism	Structure
camptothecin	-	Camptotheca acuminata
camptothecin	-	Nothapodytes nimmoniana
camptothecin	-	Ophiorrhiza pumila
isorauhimbinic acid	-	Camptotheca acuminata
isorauhimbinic acid	-	Nothapodytes nimmoniana
isorauhimbinic acid	-	Ophiorrhiza pumila
topotecan	-	Camptotheca acuminata
topotecan	-	Nothapodytes nimmoniana
topotecan	-	Ophiorrhiza pumila
yohimbinic acid	-	Camptotheca acuminata
yohimbinic acid	-	Nothapodytes nimmoniana
yohimbinic acid	-	Ophiorrhiza pumila

Organism

Organism	UniProt	Comment	Textmining
Camptotheca acuminata	B2DDA7	-	-
Nothapodytes nimmoniana	A0A097ZNA3	-	-
Ophiorrhiza pumila	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leaf	-	Nothapodytes nimmoniana	-
leaf	-	Camptotheca acuminata	-

Synonyms

Synonyms	Comment	Organism
DNA topoisomerase I	-	Ophiorrhiza pumila
DNA topoisomerase I	-	Nothapodytes nimmoniana
DNA topoisomerase I	-	Camptotheca acuminata
Top1	-	Ophiorrhiza pumila
Top1	-	Nothapodytes nimmoniana
Top1	-	Camptotheca acuminata

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Release 2023.1 (January 2023)