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Literature summary for 5.6.2.1 extracted from

  • de Oliveira Figueiredo, P.; Perdomo, R.T.; Garcez, F.R.; de Fatima Cepa Matos, M.; de Carvalho, J.E.; Garcez, W.S.
    Further constituents of Galianthe thalictroides (Rubiaceae) and inhibition of DNA topoisomerases I and IIalpha by its cytotoxic beta-carboline alkaloids (2014), Bioorg. Med. Chem. Lett., 24, 1358-1361 .
    View publication on PubMed
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
1-(hydroxymethyl)-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H-beta-carbolin-1-yl)-cyclopentanol
-
 Homo sapiens
1-methyl-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H-beta-carbolin-1-yl)-cyclopentanol
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
supercoiled DNA Homo sapiens
-
 relaxed DNA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
786-O cell
-
 Homo sapiens
-
B16-F10 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
UACC-62 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA
-
 Homo sapiens relaxed DNA
-
 ?

Synonyms

Synonyms Comment Organism
DNA topoisomerase I
-
 Homo sapiens
Top1
-
 Homo sapiens