Literature summary for 5.6.2.1 extracted from

Drwal, M.N.; Agama, K.; Wakelin, L.P.; Pommier, Y.; Griffith, R.
Exploring DNA topoisomerase I ligand space in search of novel anticancer agents (2011), PLoS ONE, 6, e25150.

Search for more literature for 5.6.2.1

Inhibitors

Inhibitors	Comment	Organism	Structure
(2S,3R)-5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-8-phenyl-2,3,8,9-tetrahydro-10H-[1,4]dioxino[2,3-f]chromen-10-one	-	Homo sapiens
1-(alpha-L-idopyranosyl)-N-(2-methylbenzoyl)-5-(methylsulfanyl)-1H-1,2,4-triazol-3-amine	-	Homo sapiens
1-[2-(dimethylamino)ethyl]-3-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]quinoxalin-2-amine	-	Homo sapiens
3-amino-4-chloro-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid	-	Homo sapiens
4-(2-hydroxyethyl)-6-([2-[(2-hydroxyethyl)amino]ethyl]amino)-1,2,3,4-tetrahydronaphtho[2,3-f]quinoxaline-7,12-dione	-	Homo sapiens
4-chloro-N-[5-imino-1-(quinoxalin-2-yl)-2,5-dihydro-1H-1,2,4-triazol-3-yl]-5-methyl-2-sulfanylbenzenesulfonamide	-	Homo sapiens
4-[[(6-amino-3-methylpyrido[2,3-b]pyrazin-8-yl)amino]methyl]benzenesulfonamide	-	Homo sapiens
6-[(2-chlorobenzyl)sulfanyl]-9-(beta-L-ribofuranosyl)-9H-purin-2-amine	-	Homo sapiens
8-bromo-9-cyano-7-(alpha-L-xylofuranosyl)-3,7-dihydroimidazo[1,2-c]pyrrolo[3,2-e]pyrimidin-4-ium	-	Homo sapiens
camptothecin	-	Homo sapiens
irinotecan	-	Homo sapiens
methyl [[5-carbamoyl-6-(methylsulfanyl)-4-oxo-3-phenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]sulfanyl]acetate	-	Homo sapiens
additional information	inhibitor design and evaluation, DNA cleavage inhibition and cytotoxic activities, docking study, overview	Homo sapiens
N-[9-acetyl-6-(benzylsulfanyl)-9H-purin-2-yl]acetamide	-	Homo sapiens
topotecan	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
DNA topoisomerase I	-	Homo sapiens
Top1	-	Homo sapiens

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Release 2023.1 (January 2023)